Prototype Testing
Use of the excised-skin model to evaluate percutaneous absorption is widespread, not only in the development of transdermal drug products but also in the development of topical drug and cosmetic products and in the field of toxicological risk assessment. In particular, the latter area has triggered a detailed review of in-vitro methodology by a number of expert groups in the last decade and has led to publication of documents that explicitly describe the manner in which researchers should conduct studies if they are to obtain quantitatively accurate results.
This article discusses the use of excised human skin for in-vitro permeation testing and the correlation of data obtained in the in-vitro permeation model and that obtained in living man.
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